Goat Antibodies Against HCV E2 Protein
Author Information
Author(s): Yasmine S El Abd, Ashraf A Tabll, Noha G Bader, Alaa El-Dien S Hosny, Rehab I Moustafa, Reem El-Shenawy, Khaled Atef, Mostafa K El-Awady
Primary Institution: National Research Center, Giza, Egypt
Hypothesis
Can caprine antibodies generated against conserved peptides of the HCV E2 protein neutralize the virus?
Conclusion
The study found that certain caprine antibodies can effectively neutralize HCV, suggesting their potential as vaccine components.
Supporting Evidence
- Goats immunized with E2 peptides produced antibodies that were 2 to 4.5 times higher than those in chronic HCV patients.
- Anti p412 and anti p517 antibodies showed 87.5% and 75% neutralization against HCV genotype 4a.
- Anti p430 exhibited weak neutralization capacity at 31.25%.
Takeaway
Scientists used goat antibodies to fight a virus that makes people sick, and they found some that worked really well.
Methodology
Goats were immunized with synthetic peptides from the HCV E2 protein, and their antibody responses were tested in vitro.
Potential Biases
Potential bias in the selection of peptides and the immunization process.
Limitations
The study was limited to a small sample size of goats and may not fully represent human responses.
Participant Demographics
Six goats were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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