Life-threatening Hyperkalemia After Zoledronic Acid for Paget's Disease
Author Information
Author(s): Panteliou Eleftheria, Young Neil, Naysmith Morag
Primary Institution: Intensive Care Unit, Department of Critical Care and Anaesthetics, Western General Hospital, Edinburgh, UK
Hypothesis
Is hyperkalemia a potential side effect of zoledronic acid infusion in patients with Paget's disease?
Conclusion
The case highlights that persistent hyperkalemia and life-threatening arrhythmias can occur following zoledronic acid infusion.
Supporting Evidence
- The patient developed hyperkalemia after his first zoledronic acid infusion.
- He suffered a cardiac arrest 10 days post-infusion.
- Persistent hyperkalemia required prolonged treatment.
- All other causes of hyperkalemia were excluded.
Takeaway
A man got very sick after receiving a medicine for his bone disease, which caused high potassium levels in his blood and made his heart stop.
Methodology
Case report detailing the clinical course of an 80-year-old man after zoledronic acid infusion.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
80-year-old Caucasian man with a history of ischemic heart disease.
Digital Object Identifier (DOI)
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