Circulating CD133+CD34+ Progenitor Cells and Stroke Severity
Author Information
Author(s): Tanya Bogoslovsky, Maria Spatz, Aneeka Chaudhry, Dragan Maric, Marie Luby, Joseph Frank, Steven Warach
Primary Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Hypothesis
Pronounced neuroinflammation inhibits neovascularization in acute ischemia, and EPC levels are inversely related to neuroinflammatory markers in early ischemic stroke patients.
Conclusion
High ICAM-1 levels are associated with low CD133+CD34+ subset of EPC, suggesting that biomarkers of neuroinflammation may predict tissue injury and stroke severity in early ischemia.
Supporting Evidence
- ICAM-1 inversely correlated with EPC subset CD133+CD34+ on day 1 and day 3.
- MMP-9 correlated with acute lesion volume on day 1.
- IL-6 correlated with admission NIHSS.
Takeaway
In stroke patients, higher levels of a specific protein (ICAM-1) are linked to lower levels of certain blood cells (EPC) that help repair blood vessels.
Methodology
The study prospectively recruited symptomatic patients with ischemic cerebrovascular disease and assessed stroke severity using MRI and blood tests.
Limitations
The study had a small sample size and lacked age- and sex-matched controls.
Participant Demographics
{"mean_age":62,"gender_distribution":{"female":53,"male":47},"race_distribution":{"caucasian":24},"NIHSS_on_admission":10}
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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