Effectiveness of Quetiapine for Adolescent Bipolar Disorder
Author Information
Author(s): Duffy Anne, Milin Robert, Grof Paul
Primary Institution: Dalhousie University
Hypothesis
Can quetiapine effectively prevent relapse in adolescents with bipolar disorder?
Conclusion
Quetiapine can successfully maintain a proportion of adolescent patients with bipolar disorder in good remission.
Supporting Evidence
- 18 out of 21 patients completed the study.
- 13 patients maintained good quality remission on quetiapine monotherapy.
- Neurocognitive performance was comparable to matched controls.
Takeaway
This study shows that some teenagers with bipolar disorder can stay stable and feel better when taking quetiapine, a type of medicine.
Methodology
The study was a 48-week open prospective trial where patients stabilized on quetiapine were monitored for relapse.
Potential Biases
Potential bias due to the open-label design and lack of randomization.
Limitations
The study had a small sample size and was not randomized or blinded.
Participant Demographics
Participants were aged 13 to 20, with a mix of bipolar I, II, and NOS diagnoses.
Statistical Information
P-Value
0.06
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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