FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
2008
FGF15 Promotes Neurogenesis and Opposes FGF8 Function During Neocortical Development
publication
10 minutes
Evidence: high
Author Information
Author(s): Borello Ugo, Cobos Inma, Long Jason E, Murre Cornelis, Rubenstein John L R
Primary Institution: University of California, San Francisco
Hypothesis
What are the roles of FGF15 in neocortical development compared to FGF8?
Conclusion
FGF15 and FGF8 have distinct signaling properties, with FGF15 promoting neural differentiation and inhibiting proliferation.
Supporting Evidence
- FGF15 suppresses proliferation and promotes differentiation in the developing telencephalon.
- FGF15 promotes expression of CoupTF1, which represses proliferation and promotes differentiation.
- FGF15 and FGF8 differentially phosphorylate ERK, AKT, and S6 in cortical cultures.
Takeaway
FGF15 helps brain cells grow up and stop dividing, while FGF8 makes them keep dividing. They work against each other in brain development.
Methodology
The study used Fgf15-/- mutant mice and primary cortical cultures treated with recombinant FGF15 to analyze the effects on neurogenesis and proliferation.
Statistical Information
P-Value
0.0019
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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