Prevalence of Campylobacter Species in Adult Crohn's Disease
Author Information
Author(s): Mahendran Vikneswari, Riordan Stephen M., Grimm Michael C., Tran Thi Anh Tuyet, Major Joelene, Kaakoush Nadeem O., Mitchell Hazel, Zhang Li
Primary Institution: University of New South Wales, Sydney, Australia
Hypothesis
What is the prevalence of Campylobacter species in adult patients with Crohn's disease and their preferential colonization sites in the human intestine?
Conclusion
The study found a high prevalence of Campylobacter concisus in patients with inflammatory bowel disease, particularly in the proximal large intestine.
Supporting Evidence
- A significantly higher prevalence of C. concisus was detected in colonic biopsies of patients with Crohn's disease compared to controls.
- Campylobacter genus-PCR positivity was 82% in patients with IBD, significantly higher than the 48% in controls.
- C. concisus was isolated from intestinal biopsies of patients with IBD.
Takeaway
Doctors looked at samples from people with Crohn's disease and found a lot of a germ called Campylobacter concisus in their intestines, especially in certain areas.
Methodology
The study analyzed 301 biopsies from 28 patients with inflammatory bowel disease and 33 controls using PCR-sequencing and Campylobacter cultivation.
Limitations
The study did not investigate the role of C. concisus in the pathogenesis of IBD.
Participant Demographics
28 patients with IBD (15 with Crohn's disease and 13 with ulcerative colitis) and 33 controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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