HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean
Author Information
Author(s): Ciapponi Agustín, Bardach Ariel, Glujovsky Demián, Gibbons Luz, Picconi María Alejandra
Primary Institution: Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina
Hypothesis
What is the prevalence of HPV types in high-grade cervical lesions and invasive cervical cancer in Latin America and the Caribbean?
Conclusion
The study provides essential data on HPV type distribution in high-grade cervical lesions and cervical cancer in Latin America and the Caribbean, which is crucial for vaccination and screening policies.
Supporting Evidence
- 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV 18.
- 53.2% of ICC cases harbored HPV 16 and 13.2% HPV 18.
- 79 studies from 18 countries were included in the analysis.
Takeaway
This study looked at how common different types of HPV are in women with serious cervical problems in Latin America and the Caribbean, helping to understand how to prevent cervical cancer.
Methodology
A systematic review and meta-analysis were conducted, including studies with at least ten cases of HSIL/ICC and HPV-type elicitation, following MOOSE and PRISMA guidelines.
Potential Biases
High risk of bias in many studies due to methodological inconsistencies.
Limitations
The cross-sectional design of most included studies, lack of representativeness, and variations in HPV type-specific sensitivity of different PCR protocols.
Participant Demographics
Women from Latin America and the Caribbean, with a mean age of 40.4 years for HSIL and 41.1 years for ICC.
Statistical Information
Confidence Interval
95% CI reported for various HPV types.
Digital Object Identifier (DOI)
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