Dengue Virus and Autophagy
2011
Dengue Virus and Autophagy
publication
Evidence: moderate
Author Information
Author(s): Heaton Nicholas S., Randall Glenn
Primary Institution: The University of Chicago
Hypothesis
Dengue virus (DENV) induces and requires autophagy for optimal RNA replication.
Conclusion
DENV-induced autophagy stimulates lipid metabolism, which is crucial for robust viral replication.
Supporting Evidence
- DENV infection induces autophagy and requires it for viral replication.
- DENV-induced autophagosomes co-localize with lipid droplets.
- Inhibition of autophagy reduces DENV replication.
- Adding free fatty acids can complement the defect in viral replication caused by autophagy inhibition.
Takeaway
Dengue virus tricks our cells into using a process called autophagy to help it make more copies of itself by using up fat stores for energy.
Methodology
The review summarizes findings from multiple studies on the role of autophagy in DENV infection and its effects on lipid metabolism.
Limitations
The review does not provide new experimental data but summarizes existing studies.
Digital Object Identifier (DOI)
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