Genetic Epidemiology of Infectious Diseases in Humans
Author Information
Author(s): Laurent Abel, Alain J. Dessein
Primary Institution: Institut National de la Sante et de la Recherche Medicale
Hypothesis
How do genetic factors influence susceptibility to infectious diseases in humans?
Conclusion
Genetic factors play a significant role in determining human susceptibility to infectious diseases, as evidenced by various studies.
Supporting Evidence
- Genetic epidemiology combines genetic and epidemiologic information to identify genes influencing disease traits.
- Recent studies have shown that specific genes can significantly affect susceptibility to diseases like malaria and schistosomiasis.
- Familial linkage studies have successfully localized genes associated with infectious diseases.
Takeaway
Some people get sick from infections because of their genes, and scientists are trying to find out which genes are involved.
Methodology
The study uses genetic epidemiology methods, including familial linkage studies and segregation analysis, to identify genes related to infectious diseases.
Potential Biases
Potential biases may arise from population admixture and statistical issues in genetic association studies.
Limitations
The study's findings may not apply universally due to variations in populations and environmental factors.
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