Bmi-1 as a Prognostic Marker in Bladder Cancer
Author Information
Author(s): Qin Zi-Ke, Yang Jian-An, Ye Yun-lin, Zhang Xing, Xu Li-Hua, Zhou Fang-Jian, Han Hui, Liu Zuo-Wei, Song Li-Bing, Zeng Mu-Sheng
Primary Institution: Sun Yat-sen University Cancer Center
Hypothesis
The study aimed to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer.
Conclusion
Bmi-1 expression is greater in bladder cancers than in adjacent normal tissues and is potentially valuable in prognostic evaluation.
Supporting Evidence
- Bmi-1 protein expression was higher in bladder cancers than in adjacent normal tissues.
- 54.3% of bladder cancers showed Bmi-1 expression compared to 16.7% in normal tissues.
- Higher Bmi-1 expression correlated with poorer survival rates.
Takeaway
Bmi-1 is a protein that can help doctors understand how serious a bladder cancer is; more of it means a worse outlook for patients.
Methodology
The study used RT-PCR, Western blot, and immunohistochemistry to analyze Bmi-1 expression in bladder cancer and adjacent normal tissues.
Limitations
The study used the old WHO grading system and did not record lymphovascular invasion.
Participant Demographics
137 patients, 115 males and 22 females, aged 14 to 72 years (mean 56 years).
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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