Reduced TGFP Expression in Bladder Cancer
Author Information
Author(s): L.M. Coombs, D.A. Pigott, M.E. Eydmann, A.J. Proctor, M.A. Knowles
Primary Institution: Marie Curie Research Institute
Hypothesis
Is reduced expression of TGFP associated with advanced disease in transitional cell carcinoma?
Conclusion
Reduced levels of TGFP1 expression are linked to more advanced disease in transitional cell carcinoma.
Supporting Evidence
- 26% of grade 1 tumors showed reduced TGFP1 levels.
- 28% of grade 2 tumors showed reduced TGFP1 levels.
- 60% of grade 3 tumors showed reduced TGFP1 levels.
- 66% of patients with reduced TGFP1 levels had disease not controllable by local resection.
Takeaway
This study found that lower levels of a protein called TGFP1 in bladder cancer might mean the cancer is more serious.
Methodology
The study analyzed TGFP1 and TGFP2 expression in 40 transitional cell carcinomas and 7 urothelial carcinoma cell lines using RNA analysis.
Limitations
The sample size is small, which may limit the generalizability of the findings.
Participant Demographics
The study included patients undergoing cystoscopic examination for bladder cancer.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.02
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