Bone Strength and Fracture Risk in Older Men
Author Information
Author(s): Sheu Yahtyng, Zmuda Joseph M, Boudreau Robert M, Petit Moira A, Ensrud Kristine E, Bauer Douglas C, Gordon Christopher L, Orwoll Eric S, Cauley Jane A
Primary Institution: University of Pittsburgh
Hypothesis
Can peripheral quantitative computed tomography (pQCT) measures of bone strength predict nonvertebral fracture risk in older men?
Conclusion
The study found that lower pQCT measures of bone strength are significantly associated with an increased risk of nonvertebral fractures in older men.
Supporting Evidence
- Men without fractures had greater bone mineral content and strength than those with fractures.
- Every standard deviation decrease in pQCT parameters was linked to increased fracture risk.
- The combination of FN aBMD and pQCT parameters improved fracture prediction.
Takeaway
This study shows that measuring bone strength with special scans can help find older men who are more likely to break bones, even if they don't have osteoporosis.
Methodology
The study used pQCT to measure bone strength in 1143 older men and followed them for an average of 2.9 years to assess fracture incidence.
Potential Biases
Potential selection bias due to the exclusion of nonwhite participants and those with missing data.
Limitations
The study had a small number of fractures and limited generalizability to other populations.
Participant Demographics
1143 white men aged 69 and older.
Statistical Information
P-Value
p<0.05
Confidence Interval
(1.4, 2.2)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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