Lipid Profile and Serum Characteristics of the Blind Subterranean Mole Rat
Author Information
Author(s): Nasser Nicola J., Kaplan Marielle, Nevo Eviatar, Aviram Michael
Primary Institution: Shaare Zedek Medical Center, Jerusalem, Israel
Hypothesis
What are the unique lipid profile and serum characteristics of the blind subterranean mole rat, Spalax?
Conclusion
The blind subterranean mole rat has a unique lipid profile with high HDL and low LDL levels, and its serum shows higher antioxidant content compared to humans and mice.
Supporting Evidence
- Spalax has lower total cholesterol and LDL levels compared to humans.
- Spalax exhibits higher HDL levels than both humans and mice.
- The antioxidant serum content in Spalax is higher than that of humans and mice.
- C reactive protein levels are significantly lower in Spalax, indicating low inflammation.
Takeaway
The blind mole rat has special blood fats that help it stay healthy underground, where it faces tough living conditions.
Methodology
Lipid profiles and serum chemistry were analyzed from blood samples of three female mole rats, compared to human and mouse samples.
Limitations
The study was limited to a small sample size of three mole rats and did not account for fasting conditions in glucose measurements.
Participant Demographics
The study involved female Spalax judaei captured in the field.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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