Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons
2008
How PDGF Receptors Affect NMDA Receptors in Brain Neurons
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Michael A Beazely, Manjula Weerapura, John F MacDonald
Primary Institution: University of Toronto
Hypothesis
The study investigates how PDGFβ receptor activation influences NMDA receptor currents through Abl kinase in hippocampal neurons.
Conclusion
The study shows that PDGFβ receptors interact with Abl kinase to regulate NMDA receptor activity in CA1 pyramidal neurons.
Supporting Evidence
- Active Abl kinase decreases NMDA-evoked currents in isolated hippocampal neurons.
- STI571, an Abl kinase inhibitor, blocks the inhibition of NMDA currents by Abl.
- PDGFβ receptor activation enhances Abl kinase phosphorylation in hippocampal neurons.
Takeaway
When certain brain receptors are activated, they can change how other receptors work, which is important for learning and memory.
Methodology
The study used isolated CA1 hippocampal neurons from Wistar rats to measure NMDA currents after applying active Abl kinase and PDGF-BB.
Participant Demographics
2–3 week old Wistar rats
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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