Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress
2011

Studying Stress in Calves After Weaning

Sample size: 28 publication 10 minutes Evidence: high

Author Information

Author(s): O'Loughlin Aran, McGee Mark, Waters Sinéad M, Doyle Sean, Earley Bernadette

Primary Institution: Teagasc, Grange, Dunsany, Co. Meath, Ireland

Hypothesis

Calves that were weaned and penned away from their dams would be more stressed than calves that were weaned and penned adjacent to their dams.

Conclusion

Weaning stress leads to an enhanced immune response in calves, characterized by increased neutrophil numbers and pro-inflammatory cytokine expression.

Supporting Evidence

  • Total neutrophil number and neutrophil:lymphocyte ratio increased significantly after weaning stress.
  • Expression of pro-inflammatory cytokine genes was up-regulated following weaning.
  • Calves penned away from their dam had higher neutrophil counts compared to those penned beside their dam.
  • Female calves showed higher expression levels of certain cytokines than male calves.

Takeaway

When calves are separated from their mothers, they get stressed, but this stress can actually help their immune system work better for a little while.

Methodology

The study involved blood sampling and analysis of immune responses in calves before and after weaning, focusing on leukocyte populations and cytokine gene expression.

Limitations

The study did not explore the long-term effects of weaning stress beyond 11 days.

Participant Demographics

Twenty-eight clinically healthy, three-quarter bred Simmental beef calves were used, including both male and female.

Statistical Information

P-Value

p<0.001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1186/1746-6148-7-45

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