Protein Glycosylation in Aspergillus fumigatus Is Essential for Cell Wall Synthesis and Serves as a Promising Model of Multicellular Eukaryotic Development
2012
Protein Glycosylation in Aspergillus fumigatus and Its Role in Cell Wall Synthesis
publication
Evidence: high
Author Information
Author(s): Jin Cheng
Primary Institution: Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Hypothesis
The investigation of glycosylation in A. fumigatus is vital for understanding fungal cell wall synthesis and multicellular eukaryotic development.
Conclusion
Glycosylation is essential for the growth, cell wall synthesis, and development of Aspergillus fumigatus.
Supporting Evidence
- Glycosylation is crucial for the growth and morphology of A. fumigatus.
- The cell wall of A. fumigatus is composed of a unique β-1,3/1,4-glucan skeleton.
- Defects in glycosylation lead to abnormal cell wall integrity and morphology.
- Glycosylation plays a role in the development of multicellular eukaryotes.
- Understanding glycosylation can help design new antifungal therapies.
Takeaway
This study shows that a special sugar process called glycosylation helps a fungus called Aspergillus fumigatus grow and stay healthy.
Methodology
The paper reviews advances in the functional analysis of protein glycosylation in A. fumigatus.
Digital Object Identifier (DOI)
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