Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance
2008
Understanding Drug Resistance in Tuberculosis
publication
Evidence: moderate
Author Information
Author(s): Raman Karthik, Chandra Nagasuma
Primary Institution: Indian Institute of Science, Bangalore, India
Hypothesis
Can we identify pathways that lead to drug resistance in Mycobacterium tuberculosis?
Conclusion
The study identifies potential pathways for drug resistance and suggests co-targets that could help in drug discovery.
Supporting Evidence
- The study derives a protein-protein interaction network for Mycobacterium tuberculosis.
- It identifies proteins involved in drug resistance mechanisms.
- Shortest paths from drug targets to resistance proteins were computed.
- The concept of 'co-targets' was proposed to counter drug resistance.
Takeaway
This study looks at how tuberculosis bacteria become resistant to drugs and suggests new ways to stop that from happening.
Methodology
A genome-scale protein-protein interaction network was constructed from the STRING database, and shortest paths to resistance proteins were computed.
Limitations
The network may contain false positives and does not capture all important interactions.
Digital Object Identifier (DOI)
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