Effects of ClearGuard™ on Allergy Symptoms
Author Information
Author(s): Jonathan Corren, Marc Lemay, Yumei Lin, Lisa Rozga, R Keith Randolph
Primary Institution: Allergy Research Foundation, Los Angeles, USA
Hypothesis
Does the combination botanical product ClearGuard™ reduce nasal allergy symptoms in patients with seasonal allergic rhinitis?
Conclusion
The combination botanical product significantly reduced nasal symptoms during the 8 hours following allergen challenge and inhibited the release of prostaglandin D2.
Supporting Evidence
- Loratadine significantly reduced total nasal symptom scores compared to placebo.
- The combination botanical product prevented the increase in prostaglandin D2 release following allergen challenge.
- Both treatments reduced nasal symptoms compared to placebo during the observation period.
Takeaway
This study tested a plant-based product for allergy relief and found it helped reduce sneezing and other symptoms after exposure to allergens.
Methodology
Twenty subjects were randomized to receive either the combination botanical product, loratadine, or placebo in a crossover design, followed by a nasal allergen challenge.
Potential Biases
Potential bias due to the small sample size and lack of knowledge about the pharmacokinetics of the botanical product.
Limitations
The study population was small, and the washout period between treatments may not have been sufficient to prevent carry-over effects.
Participant Demographics
Twenty adults aged 18 to 65, with a mean age of 38 years, including 11 women.
Statistical Information
P-Value
P = 0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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