How Rictor/TORC2 Affects Fat Storage and Growth in C. elegans
Author Information
Author(s): Kevin T. Jones, Elisabeth R. Greer, David Pearce, Kaveh Ashrafi
Primary Institution: University of California San Francisco
Hypothesis
Rictor/TORC2 regulates fat storage, body size, and development in C. elegans through the sgk-1 pathway.
Conclusion
Rictor/TORC2 influences fat storage and growth in C. elegans by activating the SGK-1 kinase, independent of AKT signaling.
Supporting Evidence
- Loss of CeRictor leads to increased fat storage and reduced body size in C. elegans.
- CeRictor functions independently of AKT and DAF-16 in regulating fat storage and growth.
- Mutations in sgk-1 mimic the phenotypes of CeRictor mutants, indicating a shared regulatory pathway.
Takeaway
This study shows that a protein called Rictor helps worms store fat and grow, and it does this by working with another protein called SGK-1.
Methodology
The study involved creating and analyzing loss-of-function mutants in C. elegans to observe changes in fat storage, body size, and development.
Limitations
The study primarily focuses on C. elegans, which may limit the generalizability of the findings to other organisms.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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