Beclin-1 Targeting for Viral Immune Escape
2011
Beclin-1 Targeting for Viral Immune Escape
publication
Evidence: moderate
Author Information
Author(s): Münz Christian
Primary Institution: Institute of Experimental Immunology, University of Zürich
Hypothesis
Viruses have developed strategies to inhibit autophagosome generation or maturation by targeting Beclin-1.
Conclusion
Viruses, including herpesviruses, HIV, and influenza A virus, inhibit macroautophagy to enhance their replication and evade immune responses.
Supporting Evidence
- Macroautophagy helps the immune system detect and destroy pathogens.
- Viruses like HIV and influenza A virus can prevent the maturation of autophagosomes to evade immune detection.
- Herpesviruses inhibit autophagosome generation to enhance their neurovirulence.
Takeaway
Some viruses can trick our body's defenses by stopping a process called autophagy, which helps fight infections. This helps the viruses survive and make more copies of themselves.
Digital Object Identifier (DOI)
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