Using HPV Testing for Women with Mild Cervical Changes
Author Information
Author(s): M Arbyn, J Roelens, P Martin-Hirsch, S Leeson, N Wentzensen
Primary Institution: Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium
Hypothesis
Is HPV-based triage effective for women with borderline and mild dyskaryosis in the UK?
Conclusion
The study confirms that HPV testing can help triage women with borderline cervical lesions, but its effectiveness varies by age and lesion type.
Supporting Evidence
- The HPV positivity rates varied widely among sites, indicating differences in test results.
- The study found that HPV rates decreased significantly with age, particularly in women with borderline dyskaryosis.
- The positive predictive values for high-grade disease were highly variable between sites.
Takeaway
This study looks at how testing for HPV can help doctors decide what to do for women with slightly abnormal cervical tests. It shows that HPV testing is useful but not perfect.
Methodology
The study involved HPV testing of over 10,000 women with borderline or mild dyskaryosis across six sites.
Potential Biases
There may be systematic over- or undercalling of cervical cytology results among different sites.
Limitations
The study's findings may not be generalizable to all populations, especially older women with mild dyskaryosis.
Participant Demographics
Women aged 25–64 with borderline or mild dyskaryosis.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 45–68%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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