Xanthene Food Dye, as a Modulator of Alzheimer's Disease Amyloid-beta Peptide Aggregation and the Associated Impaired Neuronal Cell Function
2011
Erythrosine B as a Modulator of Alzheimer's Disease Amyloid-beta Peptide Aggregation
publication
Evidence: moderate
Author Information
Author(s): Wong H. Edward, Kwon Inchan
Primary Institution: University of Virginia
Hypothesis
Can erythrosine B modulate amyloid-beta peptide aggregation and improve neuronal cell function?
Conclusion
Erythrosine B is a novel modulator of amyloid-beta aggregation that reduces associated impaired cell function.
Supporting Evidence
- Erythrosine B inhibits amyloid fibril formation and promotes the formation of stable protofibrils.
- At higher concentrations, erythrosine B significantly recovers neuronal cell function impaired by amyloid-beta.
- Immunoassays showed that erythrosine B interacts with the N-terminus of amyloid-beta, inhibiting fibril formation.
Takeaway
Erythrosine B, a food dye, helps prevent the clumping of proteins that cause Alzheimer's disease, which can protect brain cells.
Methodology
The study used transmission electron microscopy, thioflavin T fluorescence assay, and immunoassays to evaluate the effects of erythrosine B on amyloid-beta aggregation.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website