New Compounds Combining Diacylglycerol and Lipoic Acid
Author Information
Author(s): Madawala Samanthi R. P., Andersson Rolf E., Jastrebova Jelena A., Almeida Maria, Dutta Paresh C.
Primary Institution: Swedish University of Agricultural Sciences (SLU)
Hypothesis
The hybrid molecules of 1,3-diacylglycerol and lipoic acid possess synergistic and/or additive effects compared with the parent compounds against obesity, overweight, and related metabolic syndromes.
Conclusion
The study demonstrated that the new compounds have a high in vitro free radical scavenging capacity.
Supporting Evidence
- The compounds were synthesized for the first time with yields of 80% and 70%.
- The EC50 value for the most effective compound was found to be 0.21.
- The study utilized advanced techniques like RP-HPLC-MS-APCI for analysis.
Takeaway
Scientists created new compounds that combine two substances to help fight obesity and improve health. They found that these new compounds are really good at fighting harmful free radicals.
Methodology
The study involved synthesizing new compounds and testing their free radical scavenging capacity using the DPPH method.
Digital Object Identifier (DOI)
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