Abnormal glucose regulation in patients with acute heart attack
Author Information
Author(s): Knudsen Eva C, Seljeflot Ingebjørg, Abdelnoor Michael, Eritsland Jan, Mangschau Arild, Arnesen Harald, Andersen Geir Ø
Primary Institution: Ullevål University Hospital, University of Oslo, Oslo, Norway
Hypothesis
What is the prevalence of abnormal glucose regulation in patients after an acute ST-elevation myocardial infarction?
Conclusion
The prevalence of abnormal glucose regulation in STEMI patients was lower than expected, and early glucose tests may not reliably predict long-term glucose issues.
Supporting Evidence
- The prevalence of abnormal glucose regulation was 46.9% in-hospital and reduced to 24.9% at 3 months.
- 54% of patients remained in the same glucometabolic category after a repeated OGTT.
- HbA1c and admission plasma glucose were significant predictors of abnormal glucose regulation at 3 months.
Takeaway
After a heart attack, some patients might have problems with their blood sugar, but many of them might not have these problems later on.
Methodology
This was an observational cohort study that included 224 STEMI patients treated with primary PCI, with glucose tests performed in-hospital and repeated after 3 months.
Potential Biases
Potential selection bias due to exclusion of certain patients may affect the generalizability of the findings.
Limitations
The study excluded unstable patients and those with persistent hyperglycemia, which may have led to a selection bias.
Participant Demographics
The majority of participants were Caucasian males, with a median age of 58 years.
Statistical Information
P-Value
p < 0.001
Confidence Interval
95% CI 19.1, 31.4%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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