The Role of CD55 in Granulocyte Homeostasis and Host Defense
Author Information
Author(s): Veninga Henrike, Hoek Robert M., de Vos Alex F., de Bruin Alex M., An Feng-Qi, van der Poll Tom, van Lier René A. W., Medof M. Edward, Hamann Jörg
Primary Institution: University of Amsterdam
Hypothesis
Does CD55 play a significant role in granulocyte homeostasis and the immune response to bacterial infections?
Conclusion
CD55-deficient mice have increased granulocyte levels and better protection against pneumococcal pneumonia.
Supporting Evidence
- CD55-deficient mice had about twice as many granulocytes in circulation compared to wild-type mice.
- These mice showed increased survival rates when infected with Streptococcus pneumoniae.
- The study demonstrated that the increased granulocyte numbers were not due to enhanced complement activity.
Takeaway
Mice without CD55 have more white blood cells that help fight infections, making them better at surviving pneumonia.
Methodology
The study involved genetically modified mice, flow cytometry, and infection models to assess granulocyte levels and immune response.
Limitations
The study primarily focused on mouse models, which may not fully translate to human biology.
Participant Demographics
Mice were matched for age and sex.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website