Scabies Mite Peritrophins Are Potential Targets of Human Host Innate Immunity
2011
Scabies Mite Peritrophins and Human Immune Response
publication
Evidence: moderate
Author Information
Author(s): Mika Angela, Priscilla Goh, Deborah C. Holt, Dave J. Kemp, Katja Fischer
Primary Institution: Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, University of Queensland
Hypothesis
A peritrophin abundant in the scabies mite gut could activate the complement system.
Conclusion
The study identifies a novel peritrophin in scabies mites that may trigger a host immune response.
Supporting Evidence
- Scabies mites produce proteins that inhibit human complement to avoid immune damage.
- A novel peritrophin was identified in the mite gut that may interact with human immune components.
- Immunohistochemical analysis showed the localization of the peritrophin in the mite gut.
Takeaway
Scabies mites have a special protein that helps them avoid being attacked by our immune system.
Methodology
The study involved identifying a peritrophin in scabies mites and analyzing its interaction with human complement proteins.
Digital Object Identifier (DOI)
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