High Density of TCF1+ Cells Linked to Better Survival in Lung Cancer
Author Information
Author(s): Førde Dagny, Kilvær Thomas, Pedersen Mona Irene, Blix Egil S, Urbarova Ilona, Paulsen Erna-Elise, Rakaee Mehrdad, Busund Lill-Tove Rasmussen, Donnem Tom, Andersen Sigve
Primary Institution: UiT The Arctic University of Norway
Hypothesis
Does the presence of TCF1+ tumor-infiltrating lymphocytes correlate with survival in non-small cell lung cancer (NSCLC) patients?
Conclusion
High density of TCF1+ tumor-infiltrating lymphocytes is associated with improved disease-specific survival in NSCLC patients.
Supporting Evidence
- High density of TCF1+ cells was linked to improved disease-specific survival.
- Patients with high levels of CD8+PD1-TCF1+ or CD8-PD1+TCF1+ cells showed significantly increased survival.
- TCF1+ cells were found to be independent prognostic markers in multivariable analysis.
Takeaway
This study found that having more TCF1+ immune cells in lung cancer can help patients live longer.
Methodology
The study used machine learning and multiplex immunohistochemistry to analyze tissue samples from 553 NSCLC patients.
Potential Biases
Potential bias in cell detection methods could affect the results.
Limitations
The study's findings may be influenced by the difficulty in accurately detecting certain cell types and the use of tissue microarrays.
Participant Demographics
The cohort included 553 NSCLC patients, predominantly male (68%), with ages ranging from 28 to 85 years.
Statistical Information
P-Value
p=0.002 for TCF1+ density
Confidence Interval
95% CI: 0.448-0.837
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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