HIV Vaccine Study in Macaques
Author Information
Author(s): Simon Bridge, Sally A Sharpe, Mike J Dennis, Stuart D Dowall, Brian Getty, Donald S Anson, Michael A Skinner, James P Stewart, Tom J Blanchard
Primary Institution: Liverpool School of Tropical Medicine
Hypothesis
Can a heterologous prime-boost-boost vaccination regimen using DNA and recombinant poxvirus vectors effectively elicit an immune response against HIV-1 in Chinese cynomolgus macaques?
Conclusion
The study found that the vaccination regimen was poorly immunogenic, with only one macaque producing an HIV-specific antibody response that did not neutralize HIV-1.
Supporting Evidence
- The vaccine candidates showed appropriate expression of recombinant proteins.
- Only one macaque elicited an HIV-specific antibody response.
- The antibodies did not neutralize primary isolates of HIV-1.
Takeaway
Researchers tried to create a vaccine for HIV using different methods, but it didn't work well in monkeys.
Methodology
Three macaques were immunized with a prime-boost-boost regimen using DNA vaccines and recombinant poxvirus vectors, followed by assessments of antibody and T cell responses.
Limitations
The study had a small sample size and the immunogenicity was low, with only one macaque showing an antibody response.
Participant Demographics
Three male Chinese cynomolgus macaques aged 4-5 years.
Digital Object Identifier (DOI)
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