Antiviral Properties of ISG15
Author Information
Author(s): Lenschow Deborah J.
Primary Institution: Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Hypothesis
ISG15 plays a central role in the host’s antiviral response against many viruses.
Conclusion
ISG15 is critical for the host response to viral infections, as evidenced by studies showing increased susceptibility to various viruses in ISG15-deficient mice.
Supporting Evidence
- ISG15 is one of the most abundantly induced proteins during viral infection.
- Mice lacking ISG15 show increased susceptibility to multiple viruses.
- ISG15 modification of proteins may disrupt viral replication.
- ISG15 has been shown to inhibit the release of HIV and Ebola virus particles.
- Studies indicate that ISG15 can modify viral proteins, impacting their function.
Takeaway
ISG15 is like a superhero for our immune system, helping to fight off viruses. When it's missing, our body struggles to keep the bad guys away.
Methodology
The study reviews various experiments involving ISG15's role in antiviral responses, including in vitro and in vivo studies.
Limitations
The exact mechanisms by which ISG15 functions as an antiviral molecule are still largely unknown.
Digital Object Identifier (DOI)
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