Factors Affecting Posaconazole Plasma Concentrations
Author Information
Author(s): Qu Ruochen, Liu Yan, Zhao Yan, Wang Ziyi, Yuan Shizhao, Liu Shuai, Yu Jing
Primary Institution: The First Hospital of Hebei Medical University, Shijiazhuang, China
Hypothesis
What factors influence the blood concentrations of posaconazole?
Conclusion
Delayed-release tablets maintain more stable concentrations than oral suspensions and are less affected by acid-suppressing drugs.
Supporting Evidence
- Co-administration of drugs that affect posaconazole metabolism significantly reduced its concentrations.
- High-fat meals, age, and sex did not have a significant impact on posaconazole oral suspension concentrations.
- Diarrhea substantially decreased concentrations of both delayed-release tablets and oral suspension.
- Acid-suppressing agents notably decreased oral suspension concentrations but had no significant effect on delayed-release tablets.
Takeaway
This study looked at how different things, like age and other medications, can change how much of the medicine posaconazole is in your blood. It found that some forms of the medicine work better than others.
Methodology
A systematic review and meta-analysis were conducted, analyzing data from 46 studies to evaluate factors influencing posaconazole concentrations.
Potential Biases
Potential publication bias due to the low quality of some included studies.
Limitations
The study primarily focused on oral suspension and delayed-release tablet concentrations, lacking randomized controlled trials and quality variability in included studies.
Participant Demographics
The analysis included diverse patient populations, primarily immunocompromised individuals, with a total of 8,505 patients across various studies.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, -332.26 to -172.02
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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