PDE4 Inhibition Reduces Inflammation in Septic Shock
Author Information
Author(s): Link Andreas, Selejan Simina, Maack Christoph, Lenz Monika, Böhm Michael
Primary Institution: Klinik für Innere Medizin III, Universität des Saarlandes
Hypothesis
Is beta-adrenergic receptor downregulation in septic shock blunting the anti-inflammatory effects of catecholamines?
Conclusion
In septic shock, PDE4 inhibitors can maintain anti-inflammatory effects despite the downregulation of beta-adrenergic receptors.
Supporting Evidence
- In septic shock, the anti-inflammatory effects of catecholamines are blunted by downregulation of beta2-adrenergic receptors.
- PDE4 inhibitors maintain their anti-inflammatory efficacy in CD14+ monocytes despite beta-adrenergic downregulation.
- The study involved 20 healthy volunteers and 20 patients with septic shock.
Takeaway
In patients with septic shock, the usual way that certain medicines help reduce inflammation doesn't work as well, but a different type of medicine can still help.
Methodology
The study involved in vitro stimulation of peripheral blood mononuclear cells from healthy volunteers and septic shock patients, analyzing TNF-α production and receptor expression.
Limitations
The study lacks data on PDE4 levels in monocytes from control subjects and septic patients.
Participant Demographics
20 healthy volunteers (median age 49) and 20 patients with septic shock (median age 52, 10 females and 10 males).
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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