GPCR oligomers in pharmacology and signaling
2011
Understanding GPCR Oligomers in Pharmacology and Signaling
publication
Evidence: moderate
Author Information
Author(s): González-Maeso Javier
Primary Institution: Mount Sinai School of Medicine
Hypothesis
The formation of GPCR homo- and hetero-complexes is crucial for their signaling and pharmacological properties.
Conclusion
Recent advances suggest that GPCR complexes play significant roles in receptor signaling and pharmacology.
Supporting Evidence
- GPCRs were initially thought to function as monomers, but evidence now supports their existence as dimers and oligomers.
- Studies have shown that GPCR heterocomplexes can affect pharmacological responses and signaling pathways.
- Recent findings indicate that GPCR complexes are present in native tissues, not just in cell cultures.
Takeaway
GPCRs, which are important for many drugs, can work together in pairs or groups, which helps them send signals in the body.
Methodology
This review summarizes recent findings on GPCR complexes and their implications in pharmacology and signaling.
Limitations
The majority of findings are based on studies in tissue cultures rather than in whole animal models.
Digital Object Identifier (DOI)
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