Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs
2010
HIV Subtype Diversity and Antiviral Drug Resistance
publication
Evidence: moderate
Author Information
Author(s): Wainberg Mark A., Brenner Bluma G.
Primary Institution: McGill University AIDS Centre, Jewish General Hospital
Hypothesis
How does the diversity of HIV subtypes affect resistance to antiviral drugs?
Conclusion
HIV-1 subtype diversity significantly influences the type and degree of drug resistance, with non-B subtypes showing distinct resistance profiles.
Supporting Evidence
- Over 90% of HIV-1 infected people worldwide have non-subtype B variants.
- Genetic differences among HIV subtypes can lead to different patterns of drug resistance.
- Subtype C shows a higher frequency of certain resistance mutations compared to subtype B.
Takeaway
Different types of HIV can react differently to medicines, which means some might not work as well for certain people. This is important to know when treating HIV.
Limitations
The study highlights the lack of data on non-B subtypes and the challenges in obtaining resistance testing in resource-limited settings.
Digital Object Identifier (DOI)
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