CD40 Gene Variants and Fuchs Uveitis Syndrome in Han Chinese
Author Information
Author(s): Chen Feilan, Hou Shengping, Jiang Zhengxuan, Li Fuzhen, Chen Yuanyuan, Kijlstra Aize, Yang Peizeng
Primary Institution: The First Affiliated Hospital of Chongqing Medical University
Hypothesis
Are CD40 polymorphisms associated with Fuchs uveitis syndrome in Han Chinese patients?
Conclusion
The study found no association between the CD40 polymorphisms rs4810485 and rs1883832 and Fuchs uveitis syndrome in the Han Chinese population.
Supporting Evidence
- The study included 131 patients with FUS and 402 healthy controls.
- No significant differences in genotype and allele frequencies were found between patients and controls.
- The results suggest that the tested CD40 SNPs are not associated with FUS.
Takeaway
The researchers looked at two specific gene changes to see if they were linked to a type of eye disease, but they found no connection.
Methodology
Genotyping of CD40 polymorphisms was performed using PCR-RFLP on blood samples from patients and healthy controls.
Limitations
The sample size was relatively small and only included Han Chinese individuals, which may limit the generalizability of the findings.
Participant Demographics
131 Han Chinese patients with FUS (72 males, 59 females) and 402 healthy controls (241 males, 161 females).
Statistical Information
Statistical Significance
p<0.05
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