The Revolution in Viral Genomics: Analyzing Human Adenoviruses
Author Information
Author(s): Sarah Torres, James Chodosh, Donald Seto, Morris S. Jones
Primary Institution: Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, CA, USA
Conclusion
Advancements in sequencing technology have significantly improved our understanding of human adenoviruses and their molecular evolution.
Supporting Evidence
- Genomic analysis has evolved from sequencing small RNA fragments to entire adenovirus genomes.
- Comparative genomics has revealed high nucleotide identity between different adenovirus types.
- Bioinformatic tools have accelerated the study of adenovirus microevolution.
Takeaway
Scientists have learned a lot about human adenoviruses by studying their DNA over the years, and new technology helps them understand how these viruses change and evolve.
Methodology
The review discusses historical and recent advancements in genomic and bioinformatic analysis of human adenoviruses, including various sequencing methods.
Limitations
Some sequencing data contain errors that hinder comparative genomic analysis.
Digital Object Identifier (DOI)
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