MiR-886-3p and Its Role in Thyroid Cancer
Author Information
Author(s): Xiong Yin, Zhang Lisa, Holloway Alisha K., Wu Xiaolin, Su Ling, Kebebew Electron
Primary Institution: National Cancer Institute, Bethesda, Maryland, United States of America
Hypothesis
The study investigates the role of miR-886-3p in familial and sporadic papillary thyroid cancer.
Conclusion
MiR-886-3p plays a significant role in thyroid cancer cell biology and may influence the differences between familial and sporadic cases.
Supporting Evidence
- MiR-886-3p was found to be downregulated in familial papillary thyroid cancer compared to sporadic cases.
- Overexpression of miR-886-3p significantly inhibited cellular proliferation and migration in thyroid cancer cell lines.
- Pathway analysis indicated that miR-886-3p regulates genes involved in DNA replication and focal adhesion.
Takeaway
This study found that a tiny molecule called miR-886-3p helps control how thyroid cancer cells grow and move, and it acts differently in families with a history of this cancer.
Methodology
The study used microRNA profiling, quantitative RT-PCR, and various assays to analyze the effects of miR-886-3p on thyroid cancer cell lines.
Limitations
The study is limited by the small sample size and the focus on specific miRNAs without exploring other potential factors.
Participant Demographics
The study included thyroid cancer samples from both familial and sporadic cases, matched for age and gender.
Statistical Information
P-Value
p=0.028 for miR-886-3p
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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