Enzyme Activity Levels and Colorectal Cancer Survival
Author Information
Author(s): Ishikawa Masashi, Miyauchi Takayuki, Kashiwagi Yutaka
Primary Institution: National Kochi Hospital
Hypothesis
The activity levels of thymidylate synthetase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyl transferase are prognostic factors for survival in colorectal carcinoma patients treated with radical resection and adjuvant chemotherapy.
Conclusion
TS and OPRT activity levels in tumor tissue may be important prognostic factors for survival in Dukes' B and C colorectal carcinoma with radical resection and adjuvant chemotherapy.
Supporting Evidence
- OPRT activity was significantly lower in tumors with lymph node metastasis than in tumors without.
- Postoperative survival was significantly better in groups with low TS activity and/or high OPRT activity.
- The greatest increase in survival was observed for patients with both low TS activity and high OPRT activity.
Takeaway
Doctors looked at certain enzymes in cancer tissue to see if they could help predict how long patients with colorectal cancer would live after treatment.
Methodology
The study examined enzyme activity levels in fresh frozen specimens from colorectal carcinoma patients who underwent curative surgery and received adjuvant chemotherapy.
Limitations
The study is retrospective and may not generalize to all colorectal cancer patients.
Participant Demographics
23 males and 17 females, mean age of 68 years.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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