Identifying New Genetic Variants for Coronary Artery Disease
Author Information
Author(s): Nilesh J Samani, John Danesh, Hugh Watkins, Adam S Butterworth, Martin Farrall, Stephen G Ball
Primary Institution: University of Leicester
Hypothesis
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized.
Conclusion
This study identified several novel genes associated with coronary artery disease that relate to various biochemical and cellular functions.
Supporting Evidence
- Identified novel associations of variants in or near LIPA, IL5, TRIB1, and ABCG5/ABCG8 with CAD risk.
- Confirmed associations of several previously known CAD susceptibility loci.
- Found that associations in South Asians did not differ appreciably from those in Europeans.
Takeaway
Scientists looked at the genes of many people with heart disease to find new clues about why some people get sick. They found some new genes that might help us understand heart disease better.
Methodology
The study used a customized gene array to analyze 49,094 genetic variants in approximately 2,100 genes related to cardiovascular health in CAD cases and controls.
Limitations
The study did not address rare variants with a minor allele frequency of less than 1%.
Participant Demographics
The study included 15,596 CAD cases and 34,992 controls, with a mix of European and South Asian descent.
Statistical Information
P-Value
p<1.9×10−3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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