Host Genes and Infectious Diseases
Author Information
Author(s): Janet McNicholl, Gus Birkhead, Annti Vaheri, Richard Bellamy, Allen Steere, Richard Kaslow
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
Host genes influence susceptibility to infectious diseases such as hantavirus infection, tuberculosis, Lyme disease, and AIDS.
Conclusion
The study highlights the role of specific host genes in determining the severity and susceptibility to various infectious diseases.
Supporting Evidence
- Host genes like HLA-B8 are linked to more severe hantavirus disease.
- Studies in Africa show that less than 10% of TB-infected individuals become ill.
- Polymorphisms in the NRAMP1 gene are associated with increased TB risk.
- Vitamin D receptor genotypes may influence susceptibility to TB.
- HLA-DRB1*0401 alleles are associated with chronic Lyme arthritis.
- CCR5 gene variants can provide protection against HIV infection.
Takeaway
Some people get really sick from infections because of their genes, and scientists are trying to figure out which genes are involved.
Methodology
The study used case-control studies and genome scanning to identify gene-disease interactions.
Limitations
The studies primarily focused on specific populations and may not be generalizable to all groups.
Participant Demographics
The studies included populations from The Gambia and South Africa, primarily focusing on males.
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