Drug-Resistant Salmonella Paratyphi A in India
Author Information
Author(s): Dinesh S. Chandel, Rama Chaudhry, Benu Dhawan, Anita Pandey, Aparajit B. Dey
Primary Institution: All India Institute of Medical Sciences
Hypothesis
The study investigates the increasing incidence of drug-resistant Salmonella Paratyphi A in India.
Conclusion
The study found that 32% of Salmonella Paratyphi A isolates from New Delhi had decreased susceptibility to ciprofloxacin, leading to treatment failures.
Supporting Evidence
- From 1996 to 1998, isolates were uniformly susceptible to antibiotics.
- In 1998, the incidence of drug-resistant S. Paratyphi A increased to 24%.
- 32% of isolates in the first half of 1999 were resistant to both chloramphenicol and cotrimoxazole.
- Resistance to ciprofloxacin was noted with MICs greater than 2.0 mg/L.
Takeaway
Doctors found that a lot of sick people in India had a type of bacteria that didn't get better with a common medicine, making it harder to treat them.
Methodology
The study screened 105 isolates of S. Paratyphi A for drug susceptibility using disc diffusion and E-test methods.
Limitations
The study only included isolates from specific hospitals in Delhi and surrounding areas, which may not represent the entire country.
Participant Demographics
Isolates were collected from hospitals in Delhi and adjoining areas, including All India Institute of Medical Sciences and Safdarjang Hospital.
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