HIF-1α Expression in Ovarian Cancer
Author Information
Author(s): Daponte Alexandros, Ioannou Maria, Mylonis Ilias, Simos George, Minas Marcos, Messinis Ioannis E, Koukoulis George
Primary Institution: University of Thessalia, Larissa, Greece
Hypothesis
The study investigates the prognostic significance of HIF-1α expression in serous ovarian cancer.
Conclusion
HIF-1α expression is a significant independent prognostic factor for survival in poorly differentiated serous ovarian carcinoma.
Supporting Evidence
- HIF-1α expression was significantly lower in benign tumors compared to cancerous ones (p < 0.001).
- Patients with strong HIF-1α expression had a median survival of 28 months compared to 39 months for those with weak or no expression.
- HIF-1α was identified as an independent adverse prognostic factor for survival (p < 0.01).
Takeaway
This study found that a protein called HIF-1α can help predict how well patients with a certain type of ovarian cancer will do after treatment.
Methodology
The study analyzed 100 neoplastic and 20 benign samples using immunohistochemistry to assess HIF-1α expression.
Potential Biases
Potential bias due to the selection of antibodies and the interpretation of immunohistochemical results.
Limitations
The study's findings may be influenced by the methodology and the specific antibodies used.
Participant Demographics
The average age of patients with stage III, G3 serous carcinomas was 62.5 years.
Statistical Information
P-Value
p = 0.01
Confidence Interval
1.544 to 9.614
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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