Cytokines and Zinc Transporters in Beta-Cell Health
Author Information
Author(s): Egefjord Lærke, Jensen Jens Ledet, Bang-Berthelsen Claus Heiner, Petersen Andreas Brønden, Smidt Kamille, Schmitz Ole, Karlsen Allan Ertman, Pociot Flemming, Chimienti Fabrice, Rungby Jørgen, Magnusson Nils E
Primary Institution: Department of Pharmacology, University of Aarhus, Aarhus, Denmark
Hypothesis
Do pro-inflammatory cytokines regulate zinc transporter gene expression in beta-cells?
Conclusion
Cytokines influence the expression of zinc transporters in beta-cells, particularly ZnT8, which may play a role in beta-cell apoptosis.
Supporting Evidence
- Cytokines generally down regulated zinc transporter expression in both islets and INS-1 cells.
- ZnT8 was the most regulated zinc transporter, showing significant down regulation.
- Cytokine mixtures increased the down regulation of zinc transporters compared to individual cytokines.
Takeaway
Cytokines can change how beta-cells handle zinc, which might make them more likely to die. This is important for understanding diabetes.
Methodology
The study measured the effects of cytokines on zinc transporter gene expression in INS-1 cells and rat pancreatic islets.
Limitations
The study did not test TNF-α in islets, which limits conclusions about its effects.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website