The IKK Kinases: Operators of Antiviral Signaling
2010
The IKK Kinases: Operators of Antiviral Signaling
publication
Evidence: high
Author Information
Author(s): Pham Alissa M., tenOever Benjamin R.
Primary Institution: Mount Sinai School of Medicine, New York, NY, USA
Conclusion
The IKK kinases play crucial roles in regulating the antiviral immune response by integrating various cellular signals to activate transcription factors that inhibit viral replication.
Supporting Evidence
- The IKK kinases are essential for the activation of NF-κB and IRF3/7 transcription factors.
- IKKα and IKKβ have distinct roles in the antiviral response despite their functional similarities.
- TBK1 and IKKɛ are critical for the phosphorylation and activation of IRF3 and IRF7 in response to viral infections.
- Multiple signaling pathways converge at the IKK complex to regulate the immune response to viruses.
Takeaway
This study explains how certain proteins in our cells help fight off viruses by sending signals that tell the cell to produce defenses against the virus.
Methodology
The review discusses the roles of IKK and IKK-related kinases in antiviral signaling pathways, focusing on their interactions and functions in immune responses.
Digital Object Identifier (DOI)
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