Interactions of the Intestinal Epithelium with Pathogens and Microbiota
Author Information
Author(s): Srikanth C. V., McCormick Beth A.
Primary Institution: Massachusetts General Hospital and Harvard Medical School
Hypothesis
The study investigates the complex interactions between the intestinal epithelium, pathogens, and the indigenous microbiota.
Conclusion
The study highlights the critical role of the gut microbiota in maintaining intestinal health and preventing infections.
Supporting Evidence
- The gut microbiota is essential for the development and function of the mucosal immune system.
- Commensal bacteria produce metabolites that influence host health.
- Disruption of the gut microbiota can lead to increased susceptibility to infections.
Takeaway
The bacteria in our gut help keep us healthy by fighting off bad germs, and if the balance is upset, it can make us sick.
Methodology
The review discusses various experimental model systems, including germ-free and antibiotic-treated mice, to study host-microbe interactions.
Limitations
The complexity of gut flora and its interactions makes it difficult to study comprehensively.
Digital Object Identifier (DOI)
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