Pro-collagen I peptide promotes breast cancer growth and blood vessel formation
Author Information
Author(s): Visigalli Davide, Palmieri Daniela, Strangio Antonella, Astigiano Simonetta, Barbieri Ottavia, Casartelli Gianluigi, Zicca Antonio, Manduca Paola
Primary Institution: Università di Genova, Italy
Hypothesis
PICP induces epigenetic changes in breast tumor cells, resulting in promotion of tumor vascularization and progression in vivo.
Conclusion
PICP induces a metastasis-prone phenotype in breast cancer cells and promotes early vascularization of tumors.
Supporting Evidence
- PICP-treated tumors showed increased vascularization compared to control tumors.
- Pro-metastatic genes like VEGF-A and MMP-9 were up-regulated in PICP-treated tumors.
- Mitotic and apoptotic indexes were unaffected by PICP treatment.
- Endothelial cells were more frequently detected in PICP-treated tumors.
- RECK expression was down-regulated in PICP-treated tumors.
Takeaway
A special part of collagen helps breast cancer cells grow and form new blood vessels, which can make the cancer spread more easily.
Methodology
Xenografts were created in BalbC/nude mice using MDA MB231 cells treated with PICP, and tumor development was studied over 48 days.
Limitations
The study was limited to a specific mouse model and may not fully represent human breast cancer behavior.
Participant Demographics
Female BalbC/nude mice, aged 6-8 weeks.
Statistical Information
P-Value
0.0181
Statistical Significance
p = 0.0181
Digital Object Identifier (DOI)
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