Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
2009

Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis

publication Evidence: moderate

Author Information

Author(s): Mark G Goldstein, Zihai Li

Primary Institution: University of Connecticut

Hypothesis

Heat-shock proteins may provide a link between infection-mediated inflammation and subsequent cancer development.

Conclusion

Heat-shock proteins play a critical role in the relationship between infection-induced inflammation and tumorigenesis.

Supporting Evidence

  • Inflammation is a necessary component of tumorigenesis in some cancers.
  • Heat-shock proteins have been identified as mediators of the inflammatory process.
  • Chronic inflammation can lead to DNA damage and promote cancer development.

Takeaway

Infections can cause inflammation that leads to cancer, and heat-shock proteins are important in this process.

Methodology

This is a review article discussing the role of heat-shock proteins in cancer development due to infection-induced inflammation.

Limitations

The review does not provide new experimental data but synthesizes existing literature.

Digital Object Identifier (DOI)

10.1186/1756-8722-2-5

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