Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
2009
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
publication
Evidence: moderate
Author Information
Author(s): Mark G Goldstein, Zihai Li
Primary Institution: University of Connecticut
Hypothesis
Heat-shock proteins may provide a link between infection-mediated inflammation and subsequent cancer development.
Conclusion
Heat-shock proteins play a critical role in the relationship between infection-induced inflammation and tumorigenesis.
Supporting Evidence
- Inflammation is a necessary component of tumorigenesis in some cancers.
- Heat-shock proteins have been identified as mediators of the inflammatory process.
- Chronic inflammation can lead to DNA damage and promote cancer development.
Takeaway
Infections can cause inflammation that leads to cancer, and heat-shock proteins are important in this process.
Methodology
This is a review article discussing the role of heat-shock proteins in cancer development due to infection-induced inflammation.
Limitations
The review does not provide new experimental data but synthesizes existing literature.
Digital Object Identifier (DOI)
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