Emerging Mycobacterium tuberculosis Beijing Genotype in Vietnam
Author Information
Author(s): Dang Duc Anh, Martien W. Borgdorff, L.N. Van, N.T.N. Lan, Tamara van Gorkom, Kristin Kremer, Dick van Soolingen
Primary Institution: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Hypothesis
Is the spread of Mycobacterium tuberculosis Beijing genotype strains in Vietnam associated with BCG vaccination status or drug resistance?
Conclusion
The Beijing genotype is prevalent among younger TB patients in Vietnam and is associated with drug resistance but not with BCG vaccination status.
Supporting Evidence
- 301 out of 563 patients (54%) were infected with Beijing genotype strains.
- The Beijing genotype was associated with younger age and drug resistance.
- Drug resistance was more common in the Beijing genotype compared to other genotypes.
Takeaway
This study found that a specific type of tuberculosis bacteria is spreading in Vietnam, especially among younger people, and it often resists treatment.
Methodology
Analyzed 563 isolates from new TB cases using spoligotyping to assess genotype association with age, resistance, and BCG vaccination status.
Limitations
The association of the Beijing genotype and drug resistance was limited to Ho Chi Minh City due to varying resistance levels and small sample size from Hanoi.
Participant Demographics
Patients included both genders with a focus on age groups, particularly younger individuals.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.1-2.6 for isoniazid resistance; 95% CI 2.0-4.6 for streptomycin resistance
Statistical Significance
p<0.001
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