Osteoarthritis and Alzheimer's Disease in Mice
Author Information
Author(s): Stephanos Kyrkanides, Ross H. Tallents, Jennie H. Miller, Mallory E. Olschowka, Renee Johnson, Meixiang Yang, John A. Olschowka, Sabine M. Brouxhon, M. Kerry O'Banion
Primary Institution: Stony Brook University Health Science Center
Hypothesis
Localized peripheral inflammation, such as osteoarthritis, contributes to neuroinflammation and neurodegenerative disease.
Conclusion
Peripheral inflammation triggers neuroinflammation and accelerates Alzheimer's disease pathology.
Supporting Evidence
- Induction of osteoarthritis in mice led to increased neuroinflammation.
- APP/PS1 mice with osteoarthritis developed Aβ plaques earlier than those without.
- Behavioral changes were observed in mice with induced osteoarthritis.
Takeaway
When mice with arthritis were studied, they showed more signs of Alzheimer's disease, like brain plaques, than those without arthritis.
Methodology
The study used a mouse model to induce osteoarthritis and assessed its effects on neuroinflammation and Alzheimer's pathology.
Potential Biases
Potential bias in animal model selection and interpretation of results.
Limitations
The study was conducted in mice, which may not fully replicate human conditions.
Participant Demographics
Mice were 2 months old at the start of the study.
Statistical Information
P-Value
p<0.016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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