APOA2 Variants and Type 2 Diabetes
Author Information
Author(s): Duesing Konsta, Charpentier Guillaume, Marre Michel, Tichet Jean, Hercberg Serge, Balkau Beverley, Froguel Philippe, Gibson Fernando
Primary Institution: Imperial College London
Hypothesis
Are common variants in the APOA2 gene associated with type 2 diabetes and related traits in French Caucasian subjects?
Conclusion
The study found no evidence that common variants in APOA2 contribute to type 2 diabetes susceptibility in Northern Europeans.
Supporting Evidence
- None of the APOA2 tag SNPs were associated with type 2 diabetes in the French Caucasian cohort.
- The meta-analysis confirmed that common variation at the APOA2 locus is not associated with type 2 diabetes.
- The study included a large sample size of over 3,000 subjects.
Takeaway
The researchers looked at certain gene variations to see if they were linked to diabetes, but they found no connection.
Methodology
The study genotyped three tagging SNPs in a case-control cohort of 3,093 French Caucasian subjects and performed a meta-analysis.
Limitations
The study cannot rule out the possibility that rare variants or distal common variants may be associated with type 2 diabetes.
Participant Demographics
Participants were of French Caucasian ancestry, including 1,455 type 2 diabetic subjects and 1,638 normoglycaemic subjects.
Statistical Information
P-Value
P = 0.026 for cholesterol levels; P = 0.029 for waist-to-hip ratio.
Digital Object Identifier (DOI)
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