Physical Activity and Alzheimer's Biomarkers
Author Information
Author(s): Dougherty Ryan, Soldan Anja, Pettigrew Corinne, Greenberg Barry, Spira Adam, Moghekar Abhay, Albert Marilyn
Primary Institution: Johns Hopkins University
Hypothesis
Does higher physical activity modify the relationship between Alzheimer's biomarkers and cognitive function?
Conclusion
Higher levels of physical activity may protect against cognitive decline related to tau pathways in Alzheimer's disease.
Supporting Evidence
- Physical activity was measured using wrist accelerometers.
- Participants underwent lumbar puncture to collect cerebrospinal fluid.
- Higher physical activity levels were associated with better executive function scores among those with elevated tau levels.
Takeaway
Being active can help keep your brain healthy, especially if you have certain markers for Alzheimer's disease.
Methodology
Participants wore accelerometers, underwent lumbar puncture for CSF collection, and completed neuropsychological exams.
Participant Demographics
Mean age 72.2 years, 70% women.
Statistical Information
P-Value
p=.004 for total tau, p=.016 for p-tau181.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website